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Cancer Topics Index of Japan(2014.05.25~2014.05.31)「がんの本ブロク」の今週の海外がん情報とプレスリリース

ヴィトルヴィウス的人間2
Cancer Topics Index of Japan(2014.05.25~2014.05.31)

Flags 【海外:overseas】
<FDA, NIH, NCI, EMA>
Treatment helps young women preserve their fertility during breast cancer chemotherapy(若い女性の乳がんと生殖能力の維持)
Posted: 05/30/2014 NCI Press Releas
Researchers have found that young women with breast cancer were able to better preserve their fertility during cancer treatments by using hormone-blocking drug injections that put them into temporary menopause.

Tiny mutation triggers drug resistance for patients with one type of leukemia(慢性リンパ性白血病(CLL)に対する薬剤耐性)
NCI Cancer Center News (Posted: 05/29/2014)
⇒ A multi-institutional team of researchers has pinpointed exactly what goes wrong when chronic lymphocytic leukemia (CLL) patients develop resistance to ibrutinib, a highly effective, precisely targeted anti-cancer drug. In a correspondence published online May 28 in the New England Journal of Medicine, they show how the mutation triggers resistance.

Stanford study could pave way to new treatment for rare jaw tumor(スタンフォード大学:エナメル上皮腫の新しい治療法)
NCI Cancer Center News (Posted: 05/27/2014)
Researchers have identified the mutations underlying a rare, understudied type of jaw tumor called ameloblastoma, and have also found FDA-approved drugs that may help treat the tumors.

UCSD scientists find gene mutation for aggressive form of pancreatic cancer(カリフォルニア大学:腺扁平上皮癌に共通する変異遺伝子を同定)
NCI Cancer Center News (Posted: 05/27/2014)
Researchers at the University of California, San Diego School of Medicine have identified a mutated gene common to adenosquamous carcinoma tumors – the first known unique molecular signature for this rare, but particularly virulent, form of pancreatic cancer.

MD Anderson scientists discover potential new target for cancer immunotherapy(MDアンダーソン:がん免疫療法のための潜在的な新しいターゲット)
NCI Cancer Center News (Posted: 05/27/2014)
Scientists have found a way to target elusive cells that suppress immune response, depleting them with peptides that spare other important cells and shrink tumors in preclinical experiments.

Albert Einstein College of Medicine study identifies how signals trigger cancer cells to spread(アルバートアインシュタイン大学:がん細胞内のシグナル伝達経路)
NCI Cancer Center News (Posted: 05/27/2014)
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

<Medical journal>
Ibrutinib Resistance in Chronic Lymphocytic Leukemia(慢性リンパ性白血病におけるIbrutinib抵抗)
May 28, 2014DOI: 10.1056/NEJMc1402716

Metastasis from Thyroid Carcinoma(甲状腺がんからの転移)
IMAGES IN CLINICAL MEDICINE
Abhay K. Kattepur, D.N.B., M.R.C.S., and Kodaganur S. Gopinath, F.R.C.S.
N Engl J Med 2014; 370:2131May 29, 2014DOI: 10.1056/NEJMicm1312669

Cancer 1 June 2014

Cost-Effectiveness of the Children's Oncology Group Long-Term Follow-up Screening Guidelines for Childhood Cancer Survivors at Risk for Treatment-Related Heart Failure(小児がん生存者:長期フォローアップ検診ガイドラインの費用対効果)
20 May 2014 Annals of Internal Medicine

Screening for lung cancer using low dose computed tomography(肺がんのスクリーニング)
BMJ Published 27 May 2014

Researcher Behind Stem Cell Controversy Agrees to Retraction (STAP Stem Cells)
AAAS By Kelly Servick Wednesday, May 28, 2014

<others>
ASCO;American Society of Clinical Oncology (2014 Annual Meeting Daily News)

両乳房切除、非合理的に選択され過ぎている 米調査(5月23日 AFP BBNews:日本語)
⇒予防的対側乳房切除(Contralateral Prophylactic Mastectomy、CPM)

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