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Cancer Topics Index 04/13/2016(Daily Test version/ 日刊テスト版)No.09

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Cancer Topics Index 04/13/2016(Daily Test version/ 日刊テスト版) No.09

Flags 【海外:overseas】
◇NIH (National Institutes of Health)◇
【精密医学・イニシアティブ(PMI)コホートプログラム/新ディレクター】
wh_precision_medicine_header2.jpg
Selection of Eric Dishman as Director of the Precision Medicine Initiative Cohort Program (April 11, 2016 The NIH Director)
I am very pleased to announce the selection of Eric Dishman as Director of the Precision Medicine Initiative (PMI) Cohort Program. Eric will lead NIH’s effort to build the PMI landmark longitudinal research study of one million or more U.S. volunteers to expand our ability to improve health and treat disease through precision medicine. Eric comes to NIH with a deep understanding of the initiative, having played a critical role as a member of the PMI Working Group that deliberated intensively for several months last year to develop the design for this audacious study.

◇FDA (U.S. Food and Drug Administration) News◇
【承認】【17pの欠失を有する慢性リンパ性白血病】
Venetoclax (Venclexta) Tablets (April 11, 2016 FDA Approved Drugs)
On April 11, 2016, the U. S. Food and Drug Administration approved venetoclax (VENCLEXTA tablets, marketed by AbbVie, Inc. and Genentech USA, Inc.) for the treatment of patients with chronic lymphocytic leukemia (CLL) with 17p deletion, as detected by an FDA-approved test, who have received at least one prior therapy.


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※2週間前の情報を基準として掲載。一部の記事(がんと直接関連しないもの)は割愛しています。
18 studies found for: cancer | received from 03/30/2016 to 03/30/2016

【大腸がん】
1 Completed
Colorectal Cancer Study: Screening v.s. Other Diagnostics
Condition: Colorectal Cancer
Intervention:
Sponsor:Institute for Clinical and Experimental Medicine
ClinicalTrials.gov Identifier:NCT02727894

【転移性直腸結腸がん】
2 Not yet recruiting
Financial Impact Assessment Tool in Patients With Metastatic Colorectal Cancer
Conditions: Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer
Interventions: Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsor:Southwest Oncology Group
ClinicalTrials.gov Identifier:NCT02728804

【発熱性好中球減少症/乳がん/大腸がん/非小細胞肺がん】
3 Not yet recruiting
S1415CD, Prophylactic Colony Stimulating Factor Management in Patients With Breast, Colorectal or Non-Small Cell Lung Cancer Receiving Chemotherapy and With Risk of Developing Febrile Neutropenia
Conditions: Febrile Neutropenia; Stage 0 Breast Cancer; Stage 0 Colorectal Cancer; Stage 0 Non-Small Cell Lung Cancer; Stage I Colorectal Cancer; Stage IA Breast Cancer; Stage IA Non-Small Cell Lung Carcinoma; Stage IB Breast Cancer; Stage IB Non-Small Cell Lung Carcinoma; Stage IIA Breast Cancer; Stage IIA Colorectal Cancer; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIB Breast Cancer; Stage IIB Colorectal Cancer; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIC Colorectal Cancer; Stage IIIA Breast Cancer; Stage IIIA Colorectal Cancer; Stage IIIA Non-Small Cell Lung Cancer; Stage IIIB Breast Cancer; Stage IIIB Colorectal Cancer; Stage IIIB Non-Small Cell Lung Cancer; Stage IIIC Breast Cancer; Stage IIIC Colorectal Cancer; Stage IV Breast Cancer; Stage IV Non-Small Cell Lung Cancer; Stage IVA Colorectal Cancer; Stage IVB Colorectal Cancer
Interventions: Other: Preventive Intervention; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsor:Southwest Oncology Group
ClinicalTrials.gov Identifier:NCT02728596

【固形腫瘍】
4 Not yet recruiting
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors
Condition: Neoplasms
Intervention: Drug: Veliparib + VX-970 + Cisplatin
Sponsor:National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:NCT02723864

【血液学的悪性腫瘍/造血幹細胞移植/移植片対宿主病】
5 Recruiting
Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT
Conditions: Adult Hodgkin Lymphoma; Adult Myelodysplastic Syndrome; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Childhood Hodgkin Lymphoma; Childhood Myelodysplastic Syndrome; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Myelofibrosis; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Non-Hodgkin Lymphoma
Interventions: Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Other: Laboratory Biomarker Analysis; Drug: Mycophenolate Mofetil; Drug: Sirolimus
Sponsor:Stanford University
ClinicalTrials.gov Identifier:NCT02728700

【肝細胞がん/がん幹細胞】
6 Completed
Relationship Between Circulating Tumor Stem Cells and the Clinical Pathology
Conditions: Cancer Stem Cells; Postoperative Recurrence and Metastasis; Hepatocellular Carcinoma
Intervention:
Sponsor:Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier:NCT02727673

【前立腺がん】
7 Recruiting
Validation of Radioisotope Guided Lymphadenectomy for Loco-regional Staging in Patients With Intermediate or High-risk Prostate Cancer
Condition: Patient With Prostate Cancer
Interventions: Procedure: standard lymphadenectomy; Procedure: lymphadenectomy radio-isotope method
Sponsor:Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier:NCT02732392

【多発性骨髄腫】
8 Not yet recruiting
Dendritic Cell/Myeloma Fusion Vaccine for Multiple Myeloma (BMT CTN 1401)
Condition: Multiple Myeloma
Interventions: Procedure: Tumor Cell Collection; Procedure: Autologous Stem Cell Transplant; Drug: Melphalan; Procedure: Leukapheresis; Biological: Myeloma vaccine; Drug: GM-CSF; Drug: Lenalidomide
Sponsor:National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:NCT02728102

【乳がん】
9 Not yet recruiting
MRI-Based Preoperative Accelerated Partial Breast Irradiation
Condition: Breast Cancer
Intervention: Other: Phase II - Preoperative Radiation followed by Lumpectomy.
Sponsor:Medical College of Wisconsin
ClinicalTrials.gov Identifier:NCT02728076

【子宮内膜がん】
10 Not yet recruiting
Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer
Conditions: Endometrial Endometrioid Adenocarcinoma; Endometrial Mixed Adenocarcinoma; Endometrial Serous Adenocarcinoma; Endometrial Undifferentiated Carcinoma; Metastatic Endometrioid Adenocarcinoma; Recurrent Uterine Corpus Carcinoma
Interventions: Drug: Copanlisib; Other: Laboratory Biomarker Analysis
Sponsor:NRG Oncology
ClinicalTrials.gov Identifier:NCT02728258

【多発性骨髄腫】
11 Recruiting
Prospective Observational Study of Clinical and Genomic Predictors of Progression to Myeloma in Asymptomatic Monoclonal Gammopathies
Conditions: Monoclonal Gammopathy of Unknown Significance; Smoldering Multiple Myeloma
Intervention: Procedure: Blood Collection
Sponsor:M.D. Anderson Cancer Center
ClinicalTrials.gov Identifier:NCT02726750

【乳がんサバイバー】
12 Recruiting
Feasibility and Tolerability of Transcranial Direct Current Stimulation With Concurrent Cognitive Training
Condition: Breast Cancer Survivors
Interventions: Device: Transcranial Direct Current Stimulation (tDCS); Behavioral: Questionnaires
Sponsor:Memorial Sloan Kettering Cancer Center
ClinicalTrials.gov Identifier:NCT02726763

【術後疼痛】
13 Active, not recruiting
intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain
Condition: Postoperative Pain
Interventions: Drug: intrathecal morphine; Drug: intrathecal ketamine; Drug: intrathecal morphine + ketamine
Sponsor:Assiut University
ClinicalTrials.gov Identifier:NCT02726828

【肺癌/脳転移】
14 Recruiting
Clinical Evaluation of the Treatment of Intellectual Metastases by Radiosurgery Gamma Knife by Means of a Support System by Mask.
Conditions: Lung Cancer; Brain Metastases
Interventions: Device: GammaKnifePerfexion®; Device: GammaKnifeIcon®; Device: Efficast®; Device: MRI
Sponsor:Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier:NCT02732769

【マントル細胞リンパ腫】
18 Not yet recruiting
Bendamustine and Rituximab Alternating With Cytarabine and Rituximab for Untreated Mantle Cell Lymphoma
Condition: Mantle Cell Lymphoma
Interventions: Drug: Bendamustine; Drug: Rituximab; Drug: Cytarabine; Drug: Pegfilgrastim; Procedure: Leukapheresis; Drug: Filgrastim; Procedure: Autologous stem cell transplant
Sponsor:Washington University School of Medicine
ClinicalTrials.gov Identifier:NCT02728531

<Medical Journal & Other News>
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【がんと闘うための数学/免疫療法の新たなモデル】JOURNAL:Scientific Reports
Mathematics to fight cancer (04/12/2016 EurekAlert!/UNIVERSITY OF BONN)
Mathematicians and physicians at the University of Bonn have developed a new model for immunotherapy of cancer. The method could help to develop new treatment strategies and to understand why some approaches do not work with certain tumors. The study is now appearing in the technical journal Scientific Reports.

【粒子線治療に焦点】JOURNAL:International Journal of Radiation Oncology • Biology • Physics
Red Journal's May 2016 edition features special focus on particle therapy (04/12/2016 EurekAlert!/AMERICAN SOCIETY FOR RADIATION ONCOLOGY)
The International Journal of Radiation Oncology * Biology * Physics' (Red Journal) May edition is a special issue focused entirely on particle therapy. It will feature papers showcasing the "best available evidence" on the value of particle therapy, as well as editorials and commentaries about its place in the radiation therapy (RT) arsenal.

【非小細胞肺がん/クリゾチニブ耐性のメカニズム】JOURNAL:Journal of Thoracic Oncology
A novel mechanism of crizotinib resistance in a ROS1+ NSCLC patient (04/11/2016 EurekAlert!/INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER)
DENVER - Molecular analysis of a tumor biopsy from a proto-oncogene 1 receptor tyrosine kinase positive (ROS1+) patient with acquired crizotinib resistance revealed a novel mutation in the v-kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog receptor tyrosine kinase (KIT) that can potentially be targeted by KIT inhibitors.

【結婚はがん患者の生存を延長】JOURNAL:Cancer
Being married may help prolong survival in cancer patients (04/11/2016 EurekAlert!/WILEY)
New research has uncovered a link between being married and living longer among cancer patients, with the beneficial effect of marriage differing by race/ethnicity and place of birth. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings have important public health implications, given the rising numbers of unmarried individuals in the United States in addition to the growing aging population.

【大腸がん】
Baseline dietary glutamic acid intake and the risk of colorectal cancer: The Rotterdam study.(PubMed/Cancer. 2016 Mar 15)
あの「うま味成分[グルタミン酸]」で大腸がんリスク4割減―オランダ・エラスムス医療センター調査 (04/12/2016 健康百科)

Graphics 【日本国内:Japan】
<News>
【がん免疫薬】
小野薬品のがん免疫薬、売上高6倍の1260億円に 17年3月期 (04/11/2016 日本経済新聞電子版)

【前立腺がん】
日本人論文で注目 糖尿病薬[メトホルミン]で「前立腺がん」抑え込めるか (04/12/2016 日刊ゲンダイ)

【子宮頸部中等度異形成】
【がん電話相談から】子宮頸部中等度異形成の治療、急いだ方がいい? (04/12/2016 産経ニュース)

【胃がん】
もっとシェアして! 胃がんはピロリ菌の除菌で防げる一種の感染症 (04/12/2016 CIRCL)

<雑誌記事:Magazine/Medical journal>
Stockholm Public Library
◆信徒の友 (5月号)/日本キリスト教団出版局/発売日:2016年4月12日/価格(税込):586円
【タイトル】がん哲学外来レポート メディカルカフェスタッフ体験記
・「許し許されながら寄り添い合う」
 彦田加奈子(シャチホコ記念がん哲学外来メディカルカフェ代表)
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